What are the symptoms of Henoch Schonlein Purpura Nephropath2017-10-21 17:13
Rapid onset allergic reactions allergic purpura nephropathy symptoms: from allergens and in vivo protein binding, the formation of antigen. The resulting IgE antibodies are adsorbed on mast cells and release histamine and slow reacting substances. These substances cause small arteries and telangiectasia and increase vascular permeability.
Immune response to allergic purpura nephrotic symptoms: caused by the formation of antigen antibody complexes. These soluble and small molecule complexes can stimulate basophils to release histamine and 5- serotonin, and can also activate complement in the blood vessel wall and the basement membrane of the glomerulus, causing tissue damage.
The pathological changes of Henoch Schonlein Purpura Nephropathy are fibrous necrosis of blood vessel walls of capillaries and arterioles, and serous exudate and inflammatory cell infiltration around the vessels. The above lesions mainly occur in the skin, but can also occur in the heart, lung, liver and skull vessels, causing organ damage and bleeding.
Allergic Purpura Nephropathy: symptoms of kidney disease is an important aspect of the pathological changes, the light case showed renal lesions, only proteinuria; disease progression, glomerular basement membrane has extensive proliferative lesions, recurrent, large amount of fibrin, IgG, IgA and C3 so calm glomerular basement membrane and cementin, renal insufficiency; severe glomerular focal necrosis and platelet thrombus formation, renal tubular epithelial cell swelling, lumen.
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