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What is renal tubular injury

2017-03-02 16:51

The determination of blood urea nitrogen, serum creatinine and serum uric acid is still a common marker of glomerular function. Because the kidney through the renal tubular excretion of creatinine, so early kidney disease serum creatinine is generally not high, until the renal parenchymal damage, serum creatinine was increased, so the larger the clinical significance of determination of serum creatinine in end-stage renal disease

Renal tubular injury is a kind of phenomenon of renal function damage in recent years. Even cause complications. We have a very good understanding of the kidney, the following led us to understand how the renal tubule is going on, what is the renal tubular injury?.

What is renal tubular injury?

Glomerular filtration function to creatinine clearance as a routine general evaluation index, selective determination of urinary albumin creatinine clearance rate is the synergy index, evaluation of early damage by the two index of glomerular filtration function is relatively perfect.

The determination of blood urea nitrogen, serum creatinine and serum uric acid is still a common marker of glomerular function. Because the kidney through the renal tubular excretion of creatinine, so early kidney disease serum creatinine is generally not high, until the renal parenchymal damage, serum creatinine was increased, so the larger the clinical significance of determination of serum creatinine in end-stage renal disease. Simultaneous determination of urea nitrogen and creatinine is helpful for clinical diagnosis. Under normal circumstances, the ratio of urea nitrogen to creatinine (15-24):1. In kidney disease, serum urea nitrogen increased significantly more than creatinine, due to pre renal causes (especially severe intestinal bleeding) caused by urea nitrogen values increased significantly. Due to obstruction of the urinary tract and the non protein nitrogen retention, urea nitrogen and creatinine will be increased in proportion to the value at the same time. In severe renal tubular injury, blood urea nitrogen and creatinine ratio can be reduced to 10:1.

Comprehensive analysis of renal tubules

Renal tubular reabsorption function is generally used as alpha 1m, beta 2M and RBP as the evaluation index, this kind of low molecular weight protein is easy to pass through the glomerular filtration membrane, most of which is reabsorbed by the renal tubule. Once the urine appears, which reflects the tubular reabsorption dysfunction.

The clinical use of albumin as a marker of glomerular filtration function, alpha 1m as markers of renal function, routine urine test paper to make up for the ELISA and microscopy test of glomerular and tubular proteinuria.

NAG and ALP can be used as markers for the injury of proximal tubules, and NAG is a sensitive and non-specific ALP, which can be used as a supplementary marker of proximal tubule. Medullary loop damage markers based on THP.

Experts said: renal function does not necessarily lead to renal tubular injury, so in life we should always pay attention to their physical condition. If you find that the body is unwell, you must go to the hospital for timely treatment, for the treatment of any disease do not delay the treatment of the disease, so the result is more and more harm to your body.

 

If you have other kidney problems that can be viewed on other web pages, you can also consult online, or in your email, kidneyhope@yahoo.com, we'll get back to you as soon as possible.

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